Som beskrevet ovenfor kan male opleve medicinoverforbrugshovedpine ved anvendelse af paracetamol i længere perioder ad gangen.I slutningen af 1800-tallet fandt en tysk kemiker ud af, at virkningen skyldes stoffet acetylsalicylsyre. Det fik lægemiddelfirmaet Bayer til at udvikle Aspirin og senere Kodimagnyl, der hurtigt blev en stor succes verden

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